Topoisomerase I inhibitor 17, CAS [[2413582-45-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: Topoisomerase I inhibitor 17, CAS [[2413582-45-1]] Preis auf Anfrage
• Artikelnummer: TGM-T203609
• Hersteller Artikelnummer: T203609
• Alternativnummer: TGM-T203609-10MG,TGM-T203609-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

TopoisomeraseI inhibitor 17 (Compound 7h) is an inhibitor of TopoisomeraseI (Top1). It reduces DDX5 and reverses the locking effect of DDX5 on Top1 activity. This compound induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. It triggers apoptosis by decreasing anti-apoptotic proteins XIAP, Bcl-2, and Survivin, while increasing pro-apoptotic proteins Bax and gammaH2AX. Moreover, TopoisomeraseI inhibitor 17 halts progression at the G2/M checkpoint, leading to cell cycle arrest. It significantly impairs colorectal cancer cell colony formation and migration, and effectively reduces tumor size in human PDX tumor mouse models.

Produkteigenschaften

• Molekulargewicht: 516.47
• CAS Nummer: [2413582-45-1]
• Formel: C28H21FN2O7
• Target-Kategorie: Reactive Oxygen Species|||IAP|||Topoisomerase|||DNA/RNA Synthesis|||Survivin|||Apoptosis|||Bcl-2 Family

Bilder

T203609