ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 µM against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.
Molekulargewicht:
344.75
CAS Nummer:
[2342576-75-2]
Formel:
C17H13ClN2O4
Target-Kategorie:
Phospholipase
T203687
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