BG11 promotes the accumulation of Fe2+ and intracellular lipid peroxides, leading to ferroptosis (iron-dependent cell death). It regulates the expression of Bax and Bcl-2 proteins, inducing apoptosis (programmed cell death) in MDA-MB-231 cells. BG11 also causes cell cycle arrest at the G0/G1 and S phases, inhibiting the proliferation of TNBC cancer cells, with IC50 values of 0.49 µM for MDA-MB-231 and 0.52 µM for BT549. Additionally, it reduces cell migration and invasion and demonstrates antitumor effects in mouse models.
Molekulargewicht:
559.511
CAS Nummer:
[3065877-52-0]
Formel:
C26H28Cl2N6O2S
Target-Kategorie:
Apoptosis|||Ferroptosis
T204261
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