KT-253 is a p53 stabilizer and a PROTAC degrader of MDM2 (DC50=0.4 nM). It inhibits the proliferation of cancer cells RS4,11 with an IC50 of 0.3 nM, induces cell cycle arrest in the G2/M phase, and triggers apoptosis. In mouse models, KT-253 demonstrates antitumor activity. (Pink: ligand for target protein MDM2 ligand 4, Black: linker, Blue: ligand for E3 ligase cereblon)
Molekulargewicht:
912.874
CAS Nummer:
[2713618-08-5]
Formel:
C48H52Cl2FN7O6
Target-Kategorie:
MDM-2/p53|||Apoptosis|||PROTACs
T204319
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