GSK-3beta inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3beta and GSK-3alpha with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.
Molekulargewicht:
434.299
CAS Nummer:
[3116731-08-6]
Formel:
C18H13Cl2N5O2S
Target-Kategorie:
GSK-3
T204398
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
