HDAC6degrader-5 (Compound 6) exhibits inhibitory and degradative activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. It suppresses the release of TNF-alpha, IL-1beta, and IL-6, and prevents apoptosis in liver cells. Additionally, HDAC6degrader-5 demonstrates anti-inflammatory properties in a mouse model of APAP-induced liver injury.
Molekulargewicht:
378.424
CAS Nummer:
[3099659-64-7]
Formel:
C21H22N4O3
Target-Kategorie:
HDAC|||Interleukin|||Apoptosis
T204412
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