LD4172 is a PROTAC degrader capable of degrading RIP kinase (RIPK1) with a DC50 in the nanomolar range. When used in combination with TNF-alpha, LD4172 can induce apoptosis in B16F10 cells. In mouse models, it demonstrates antitumor activity. (Pink: ligand for target protein, Black: linker, Blue: ligand for E3 ligase VHL)
Molekulargewicht:
1149.37
CAS Nummer:
[2782022-40-4]
Formel:
C61H75F3N10O7S
Target-Kategorie:
PROTACs|||RIP kinase
T204416
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