RD-23 is an orally active and selective RET PROTAC degrader. It facilitates the ubiquitination and degradation of the RETG810C mutant with a DC50 value of 11.7 nM. Additionally, RD-23 inhibits the activation of downstream Shc signaling and induces apoptosis (Apoptosis). It is useful for studying RET-related cancers.
Molekulargewicht:
913.079
CAS Nummer:
[3053537-06-4]
Formel:
C52H56N12O4
Target-Kategorie:
Apoptosis|||PROTACs|||c-RET
T204442
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