TDI-015051, CAS [[3052313-73-9]] Preis auf Anfrage

Produktübersicht

• Artikelname: TDI-015051, CAS [[3052313-73-9]] Preis auf Anfrage
• Artikelnummer: TGM-T204648
• Hersteller Artikelnummer: T204648
• Alternativnummer: TGM-T204648-10MG, TGM-T204648-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of 0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as alpha-hCoV-NL63, alpha-hCoV-229E, and beta-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.

Produkteigenschaften

• Molekulargewicht: 471.505
• CAS Nummer: [3052313-73-9]
• Formel: C22H22FN5O4S
• Target-Kategorie: DNA Methyltransferase|||SARS-CoV

Bilder

T204648