Tubulin polymerization-IN-72 (Compound 4a4) is a microtubule synthesis inhibitor with anticancer properties. By binding to the colchicine site, it disrupts the polymerization of tubulin, resulting in the arrest of cancer cells at the G2/M phase and inducing apoptosis (Apoptosis). The IC50 for its activity against cancer cells is 0.4-2.7 nM.
Molekulargewicht:
338.379
Formel:
C19H19FN4O
Target-Kategorie:
Apoptosis|||Microtubule Associated
T204652
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