AB8939 is a potent small-molecule inhibitor of microtubule/tubulin polymerization, exhibiting antitumor activity (with tumor cell proliferation inhibition IC5010 nM). It effectively circumvents resistance mechanisms mediated by P-glycoprotein and myeloperoxidase. AB8939 can induce G2/M phase cell cycle arrest and apoptosis.
Molekulargewicht:
392.451
CAS Nummer:
[1974336-09-8]
Formel:
C22H24N4O3
Target-Kategorie:
Microtubule Associated|||Apoptosis
T204846
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