NDM-1 inhibitor-8 (Compound 18b) is a covalent inhibitor of New Delhi metallo-beta-lactamase-1 (NDM-1), with an IC50 of 7.03 µM. It effectively inhibits resistant bacterial strains and demonstrates synergistic antibacterial effects when used in combination with Meropenem. In mouse models, NDM-1 inhibitor-8 exhibits anti-infective activity.
Molekulargewicht:
647.43
Formel:
C28H23Cl2N3O4SSe
Target-Kategorie:
Beta-lactamase|||Antibacterial
T204912
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