A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 µM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.
Molekulargewicht:
442.571
CAS Nummer:
[681245-85-2]
Formel:
C24H30N2O4S
Target-Kategorie:
Aminopeptidase
T204983
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