TRPV1-IN-3 (compound 14) is a TRPV1 inhibitor utilized in idiopathic pulmonary fibrosis research. It demonstrates antifibrotic activity in vitro (IC50 = 0.51 µM) by inhibiting the TGF-beta/Smads and MAPK pathways, thereby affecting the expression of fibrosis markers collagen I and alpha-SMA. In vivo, TRPV1-IN-3 significantly reduces collagen deposition in lung tissue, improves alveolar structure, and increases survival rates in mice with Bleomycin-induced pulmonary fibrosis.
Molekulargewicht:
296.36
CAS Nummer:
[87657-67-8]
Formel:
C19H20O3
Target-Kategorie:
TRP/TRPV Channel
T205201
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