KOR agonist 4 (compound 39) is an agonist targeting the kappa opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPgammaS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the kappa opioid receptor over the µ (MOR) and delta (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.
Molekulargewicht:
319.44
Formel:
C21H25N3
Target-Kategorie:
Opioid Receptor
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
