LYG-409 is an orally active GSPT1 degrader. It demonstrates exceptional in vivo anti-tumor activity against acute myeloid leukemia and prostate cancer, with tumor growth inhibition rates (TGI) of 94.34% and 104.49%, respectively. LYG-409 inhibits KG-1 cells by degrading GSPT1, with an IC50 of 9.50 nM and a DC50 of 7.87 nM in vitro.
Molekulargewicht:
515.438
CAS Nummer:
[3053857-55-6]
Formel:
C25H20F3N3O6
Target-Kategorie:
Molecular Glues
T205349
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