Menin-KMT2A-IN-1 (Compound 20) is an inhibitor of menin-KMT2A, binding to menin with an IC50 of 8 nM, and disrupting the interaction between menin and lysine methyltransferase 2A (KMT2A). It inhibits hERG channels with an IC50 of 65 µM and suppresses MV4-11 cells with an IC50 of 74 nM. Furthermore, Menin-KMT2A-IN-1 exhibits favorable pharmacokinetic properties in CD-1 mice, with an oral bioavailability of 74%.
Molekulargewicht:
522.61
Formel:
C28H35FN6O3
Target-Kategorie:
Epigenetic Reader Domain|||Potassium Channel
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