GI-Y2 is a GSDMD inhibitor that suppresses macrophage pyroptosis induced by oxidized low-density lipoprotein (ox-LDL). In vivo, GI-Y2 dose-dependently reduces atherosclerotic plaques and decreases lesion size and fibrosis in the aortic root of ApoE-/- mice. GI-Y2 holds potential for research in pyroptosis and cardiovascular diseases, such as atherosclerosis.
Molekulargewicht:
386.379
CAS Nummer:
[1008710-58-4]
Formel:
C18H14N2O6S
Target-Kategorie:
Pyroptosis
T206350
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