hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-alpha, IL-1beta) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinsons and Alzheimers.
Target-Kategorie:
Monoamine Oxidase|||Interleukin|||TNF
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