APD-94 is a dual inhibitor targeting tubulin and Bmi-1. It disrupts the normal polymerization of tubulin and suppresses the expression of Bmi-1. This compound induces cell cycle arrest at the G2/M phase and triggers apoptosis, thereby inhibiting cancer cell proliferation. Additionally, APD-94 inhibits the growth of HT29 cell xenograft tumors in NOD/SCID mice and is applicable to colorectal cancer research.
Molekulargewicht:
339.345
CAS Nummer:
[877810-03-2]
Formel:
C18H17N3O4
Target-Kategorie:
Apoptosis|||BMI-1|||Microtubule Associated
T206828
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