CS4 is a selective HDAC inhibitor, with IC50 values for HDAC1, HDAC6, HDAC8, HDAC4, and HDAC11 reported as 38 nM, 12 nM, 5.8 µM, 19 µM, and 61 µM, respectively. It enhances the acetylation of alpha-tubulin and histone 3 (histone 3). Additionally, CS4 activates PPARgamma and blocks glycolysis (glycolysis). It induces cell cycle arrest at the G2 phase and triggers apoptosis (apoptosis), exhibiting anticancer effects both in vitro and in vivo.
Target-Kategorie:
Apoptosis|||PPAR|||HDAC
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