TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 µM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.
Molekulargewicht:
477.762
CAS Nummer:
[875165-39-2]
Formel:
C19H14BrClN4O2S
Target-Kategorie:
Proteasome
T206909
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