(S)-dHTC1 is a molecular glue degrader specifically targeting the transcriptional coactivator ENL. It exhibits high affinity binding to E3 ligase only upon formation of the ENL:(S)-dHTC1 complex, with an IC50 of 93 nM. In MV4,11 cells, (S)-dHTC1 degrades ENL with a DC50 of 26 nM. This compound can be utilized for acute myeloid leukemia research.
Molekulargewicht:
676.786
CAS Nummer:
[3081383-46-9]
Formel:
C33H40N8O6S
Target-Kategorie:
PROTACs
T206969
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