NLRP3-IN-75 is an orally effective inhibitor of NLRP3, capable of suppressing IL-1beta secretion with an IC50 of 23 nM. It selectively inhibits NLRP3 activation by disrupting inflammasome assembly without affecting the assembly of NLRC4 or AIM2 inflammasomes. NLRP3-IN-75 demonstrates excellent anti-inflammatory effects in models of acute peritonitis, diabetic nephropathy, and inflammatory bowel disease (IBD).
Target-Kategorie:
NF-kappaB|||NOD-like Receptor (NLR)|||Interleukin
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