RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4,14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.
Molekulargewicht:
266.215
CAS Nummer:
[313527-11-6]
Formel:
C12H6N6O2
Target-Kategorie:
Histone Methyltransferase
T206998
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