Rapaglutin E (RgE) is an inhibitor of glucose transport proteins (GLUT). It exhibits dose-dependent inhibition of [3H]-2DG uptake in A549, Jurkat T, PANC10.05, and RBC cells, with IC50 values of 8.9 nM, 3.1 nM, 35.5 nM, and 74.2 nM, respectively. Additionally, Rapaglutin E suppresses cell proliferation in A549, PANC10.05, HeLa, Jurkat T, and HEK293T cells.
Formel:
C67H88N6O15
Target-Kategorie:
transporter
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