MBL-IN-5 is an inhibitor of metallo-beta-lactamase (MBL). It effectively suppresses three clinically significant B1 subfamily MBLs: NDM-1, VIM-1, and IMP-1 with IC50 values of 0.05 nM, 14 nM, and 21 nM respectively. MBL-IN-5 notably enhances the efficacy of carbapenem antibiotics against MBL-producing clinical strains and, when combined with IPM antibiotics, significantly reduces bacterial load in a thigh infection model.
Molekulargewicht:
353.8
CAS Nummer:
[2876921-34-3]
Formel:
C20H16ClNO3
Target-Kategorie:
Beta-lactamase|||Antibacterial
T207135
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