BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC-type degrader (AR: DC50= 3.7 nM, AR-V7: DC50= 3.0 nM, GSPT1: DC50= 1.2 nM). It facilitates the ubiquitination and degradation of AR/AR-V7 and, through molecular glue properties, induces a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 is applicable in prostate cancer research.
Formel:
C42H46ClN5O7
Target-Kategorie:
Molecular Glues|||PROTACs|||Androgen Receptor
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