Insecticidal agent 24 is an orally active pyridinyl spiroindoline lead compound. It demonstrates antimalarial activity with Pf NF54IC50 of 0.08 µM. Insecticidal agent 24 also inhibits hERG activity with an IC50 of 6.5 µM. In a humanized immunodeficient NSG mouse model of malaria infection, it effectively reduces parasitemia.
Formel:
C26H29N3O2
Target-Kategorie:
Parasite
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
