CLK2/3-IN-1 (Compound 7c) is an orally active inhibitor of CLK2/3, with EC50 values of 5.07 nM and 30.03 nM, respectively. Its inhibitory action is facilitated by hydrogen bonding with Lys193 and Lys186 residues of CLK2/3. This compound effectively inhibits the proliferation of SW480 tumor cells with an IC50 of 163 nM and is applicable for research into CLK-related cancer diseases.
Formel:
C24H25N7O
Target-Kategorie:
CDK
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