EGFR/DHFR-IN-2 (9b) is a dual inhibitor of h-DHFR/EGFR TK, exhibiting IC50 values of 0.192 µM for h-DHFR and 0.109 µM for EGFR. It causes cell cycle arrest at the G1/S phase and induces apoptosis. Additionally, EGFR/DHFR-IN-2 (9b) is a potential inhibitor of CYP2C9 and CYP3A4. This compound can be utilized in cancer research.
Formel:
C24H16N4O5
Target-Kategorie:
Apoptosis|||Cytochromes P450|||DHFR|||EGFR
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