OPB-3206 is a selective inhibitor of matrix metalloproteinases (MMPs). It inhibits stromelysin, collagenase, gelatinase A (MMP-2), and gelatinase B (MMP-9) with IC50 values of 7*10 -7 M, 5*10 -6 M, 5*10 -7 M, and 2*10 -6 M, respectively. OPB-3206 reversibly binds to the zinc-binding site of MMPs, blocking the activation of MMP-9 and reducing the degradation of the extracellular matrix, thereby inhibiting tumor lung metastasis. OPB-3206 shows potential for research in osteosarcoma lung metastasis.
Molekulargewicht:
363.41
CAS Nummer:
[166245-54-1]
Formel:
C18H25N3O5
Target-Kategorie:
MMP
T207397
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
