DM-4107 is a primary metabolite of Tolvaptan, primarily metabolized by the CYP3A4 enzyme in the liver. In SCHH cells, DM-4107 inhibits the human liver transport proteins NTCP, BSEP, MRP3, and MRP4, with IC50 values of 95.6, 119, 61.2, and 37.9 µM respectively, affecting bile acid transport. It is applicable for research on autosomal dominant polycystic kidney disease (ADPKD).
Molekulargewicht:
480.94
CAS Nummer:
[1346599-75-4]
Formel:
C26H25ClN2O5
Target-Kategorie:
P-gp
T207521
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