ABP/PPAR modulator 1 is an orally active multi-regulator of FABP and PPAR, exhibiting IC50 values of 0.65 µM for FABP1 and 1.08 µM for FABP4, and EC50 values of 9.19 µM, 2.20 µM, and 1.58 µM for PPARalpha, PPARgamma, and PPARdelta, respectively. It demonstrates potent activity against metabolic dysfunction-associated steatohepatitis (MASH). Additionally, ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.
Molekulargewicht:
561.67
Formel:
C33H39NO7
Target-Kategorie:
FABP|||PPAR
T207742
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