LD2 is a protein arginine methyltransferase 9 (PRMT9, IC50 = 0.9 µM) inhibitor. It can reduce the proliferation ability of Rec-1 and Raji lymphoblast cells, UPN1 mantle cell lymphoma, BL-41 Burkitt lymphoma, and OCI-Ly3 diffuse large B-cell lymphoma (DLBCL) cells (IC50s = 2.5-5 µM). LD2 (2.5 µM) can induce G2/M phase cell cycle arrest in THP-1 acute myeloid leukemia (AML) cells and reduce the phosphorylation levels of checkpoint kinases 1 (Chk1) and Chk2 in their cells.
Molekulargewicht:
247.68
CAS Nummer:
[1134334-55-6]
Formel:
C12H10ClN3O
Target-Kategorie:
Others|||Histone Methyltransferase
T207769
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