2-Pyridinamine, 4-[3-fluoro-5-(4-morpholinyl)phenyl] (Compound 9l) is an ATP-competitive JNK (c-Jun N-terminal kinase) inhibitor with IC50 values of 0.099 µM and 0.148 µM for JNK1 and JNK3 respectively, exhibiting the advantage of blood-brain barrier penetration. 2-Pyridinamine, 4-[3-fluoro-5-(4-morpholinyl)phenyl] inhibits c-Jun phosphorylation and reactive oxygen species (ROS) generation, making it suitable for neurodegenerative disease research.
Molekulargewicht:
502.54
Reinheit:
99.94%
CAS Nummer:
[1128096-64-9]
Formel:
C26H27FN8O2
Target-Kategorie:
JNK|||ROS
T207823
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