PVD-06 is a selective PROTAC-based degrader of PTPN2 (with a selectivity index of greater than 60-fold over PTP1B) and exhibits anticancer activity. It induces the degradation of PTPN2 through ubiquitination and proteasome-dependent pathways. PVD-06 also enhances T cell activation and amplifies IFN-gamma-mediated cytotoxicity.
Molekulargewicht:
1074.13
CAS Nummer:
[3032975-48-4]
Formel:
C48H55F4N9O11S2
Target-Kategorie:
PROTACs|||Phosphatase
T208238
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