Thalidomide-O-C5-azide is a modified form of the cereblon (CRBN) inhibitor thalidomide, created through click chemistry. It contains an azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkynyl-containing molecules. Thalidomide-O-C5-azide serves as a ligand and linker conjugate for E3 ubiquitin ligase, facilitating the synthesis of PROTACs.
Molekulargewicht:
385.37
CAS Nummer:
[2411098-96-7]
Formel:
C18H19N5O5
Target-Kategorie:
E3 Ligase Ligand-Linker Conjugates
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