EGFR-IN-94 (compound 5a) is an EGFR inhibitor with an IC50 of 0.086 µM. It exhibits IC50 values of 0.107 µM for VEGFR-2 and 2.52 µM for Topo II. In HepG-2 cells, EGFR-IN-94 induces apoptosis and causes cell cycle arrest at the S phase.
Formel:
C19H17ClN8OS
Target-Kategorie:
Apoptosis|||VEGFR|||EGFR
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