AChE-IN-51 (compound 8C) is an orally active, non-competitive inhibitor of AChE and BChE, with IC50 values of 84 nM and 97 nM, respectively. It also inhibits MMP-2 and amyloid beta Abeta1-42 aggregation, with IC50 values of 724 nM and 302 nM. Exhibiting low cytotoxicity, AChE-IN-51 is predicted by computational models to penetrate the blood-brain barrier, making it a useful compound for research into diseases such as Alzheimers disease (AD).
Formel:
C23H21OP
Target-Kategorie:
MMP|||Cholinesterase (ChE)|||Beta Amyloid
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