HDAC6-IN-31 (compound 8m) is a selective HDAC6 inhibitor with an IC50 of 0.026 µM. It significantly suppresses the production and release of pro-inflammatory cytokines. HDAC6 plays a crucial role in inhibiting inflammasome activation and holds potential for treating NLRP3 inflammasome-driven inflammatory diseases. Additionally, HDAC6-IN-31 inhibits the migration of glioblastoma cells.
Formel:
C15H13FN4O2
Target-Kategorie:
HDAC
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