MPD2 is a PROTAC compound based on a Cereblon-binding ligand that degrades the main protease MPro of SARS-CoV-2. In 293T cells, it effectively reduces MPro protein levels with a DC50 of 296 nM and shows time-dependent activity. MPD2 exhibits strong antiviral properties against various SARS-CoV-2 strains and has increased potency against Nirmatrelvir-resistant variants. It holds potential for researching SARS-CoV-2 diseases.
Formel:
C51H68N6O13
Target-Kategorie:
SARS-CoV|||PROTACs
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
