MS181 (compound 1) is an efficient PROTAC degrader that recruits cereblon (CRBN) and binds to the ubiquitin complex polycomb repressive complex 1 (PRC1). It reduces the expression of EED, EZH2, SUZ12, BMI1, and RING1B, and exhibits antiproliferative activity.
Formel:
C39H41N11O6
Target-Kategorie:
E1/E2/E3 Enzyme|||PROTACs
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