NF449 is a potent antagonist of the P2X1 receptor, displaying IC50 values of 0.28 nM, 0.69 nM, and 120 nM for rP2X1, rP2X1+5, and P2X2+3, respectively. It acts selectively against Gsalpha G proteins (G Protein). NF449 inhibits the binding rate of GTP[gammaS] to Gsalpha-s, suppresses the stimulation of adenylate cyclase activity, and blocks the coupling of beta-adrenergic receptors with Gs.
Molekulargewicht:
1329.24
CAS Nummer:
[389142-38-5]
Formel:
C41H32N6O29S8
Target-Kategorie:
P2X Receptor
T210023
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
