2-MeSADP (2-Methylthioadenosine diphosphate, 2-Methylthio-ADP) is a potent agonist of purinergic (P2Y) receptors, displaying EC50 values of 19 nM for human P2Y13, 6.2 nM for mouse P2Y13, and 5 nM for human P2Y12. It also has pEC50 values of 8.29 for human P2Y1 and 5.75 for rat P2Y6. 2-MeSADP induces platelet aggregation and morphological changes, while inhibiting the accumulation of cyclic adenosine monophosphate in platelets in the presence of prostaglandin E1.
Molekulargewicht:
473.29
CAS Nummer:
[34983-48-7]
Formel:
C11H17N5O10P2S
Target-Kategorie:
P2Y Receptor
T210054
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