MC-ND-18 is an ATTEC degrader that facilitates the degradation of NLRP3 via autophagy, exhibiting a DC50 of 125.5 nM in THP-1 cells. It is composed of an NLRP3 ligand, a linker, and an LC3 ligand.
Formel:
C42H42Br2IN3O9S
Target-Kategorie:
NOD-like Receptor (NLR)|||PROTACs|||ATTECs
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