SmCB1-IN-1 (Compound 2h) is an inhibitor of the Schistosoma mansoni cathepsin B1 (SmCB1) with a Ki of 0.05 µM. It demonstrates selectivity towards non-target human proteases, showing inhibition rates of 29% for CatB and 37% for CatL at 20 µM. At 1 µM, SmCB1-IN-1 inhibits 68% of Schistosoma mansoni.
Formel:
C26H25NO6S
Target-Kategorie:
Cysteine Protease|||Parasite
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