SRI-31142 is a proposed brain-penetrant allosteric inhibitor of the dopamine transporter (DAT). In behavioral studies utilizing intracranial self-stimulation (ICSS), SRI-31142 does not produce the abuse-related effects observed with cocaine and GBR-12935. Instead, at effective doses, it reduces ICSS responding and dopamine levels in the nucleus accumbens (NAc). Additionally, SRI-31142 can prevent cocaine-induced increases in ICSS and NAc dopamine.
Molekulargewicht:
456.54
CAS Nummer:
[1940118-04-6]
Formel:
C29H24N6
Target-Kategorie:
Dopamine Receptor
T210311
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