Apalcillin (PC-904) combined with Ro 48-1220 (a penicillin sulfone beta-lactamase inhibitor) exhibits broad-spectrum activity against Gram-negative aerobic and anaerobic bacteria, excluding Klebsiella acid-producing strains. This combination shows strong efficacy against beta-lactamase-producing Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae with an effective MIC of 11 µg/mL. Additionally, it inhibits Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter at low MICs (0.25 to 4 µg/mL). However, it has limited efficacy against oxacillin-resistant staphylococci and some Gram-positive bacteria. Apalcillin/Ro 48-1220s effectiveness against certain extended-spectrum beta-lactamase-producing Escherichia coli is comparable to piperacillin/tazobactam, though it is less effective against SHV-type beta-lactamases.
Molekulargewicht:
521.55
CAS Nummer:
[63469-19-2]
Formel:
C25H23N5O6S
Target-Kategorie:
Antibacterial
T210324
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