ETN029 is a ligand targeting DLL3. The 225Ac-labeled ETN029 exhibits dose-dependent cytotoxic effects on small cell lung cancer (SCLC), neuroendocrine prostate cancer (NEPC), and metastatic melanoma cells, and can induce H2AX phosphorylation. The 177Lu-labeled ETN029 has rapid tumor uptake, sustained retention, and a favorable tumor-to-renal distribution ratio. Therefore, ETN029 can be used for imaging and mechanism studies of tumors such as SCLC and NEPC.
Molekulargewicht:
2142.48
CAS Nummer:
[3066864-32-9]
Formel:
C101H140N22O26S2
Target-Kategorie:
Gamma-secretase
T210498
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
